treatment
Caring for health through understanding: modern methods of combating celiac disease
Diet
To date, the only effective treatment for celiac disease is a gluten-free diet. It is believed that strict and lifelong adherence to this diet causes remission in patients with celiac disease and leads to partial or complete healing of the duodenal mucosa.
- Negative impact on quality of life and psychological problems: Following a gluten-free diet can negatively impact patients' quality of life, causing psychological problems such as fear of involuntary or irreversible gluten consumption.
- Possible vitamin and mineral deficiencies, metabolic syndrome, and increased risk of cardiovascular disease: Following a gluten-free diet can lead to possible vitamin and mineral deficiencies, an increased risk of developing metabolic syndrome, and may also increase the likelihood of cardiovascular disease.
- Frequent severe constipation: Patients following a gluten-free diet often experience severe constipation, which can be one of the negative aspects of this diet.
There is also some evidence that a gluten-free diet may even reduce the risk of cancer in these patients. However, these advantages come with some disadvantages
All of this can be overcome by educating the patient about the risks of an unsupervised gluten-free diet, providing nutritional advice from a dietitian with experience in celiac disease, and providing psychological support.
In order for the treatment of celiac disease to give the desired result, it is necessary to act in several directions. The first is the restoration of all intestinal functions. The second is correcting body weight to a healthy state, and the third is eliminating the deficiency of vital substances necessary for health.
Rules for gluten-free cuisine
Hygienic surface preparation:
After preparing foods containing gluten, thoroughly wipe surfaces using separate wipes for the gluten-free area.
Safe preparation:
Use separate cutting boards, pots and pans for gluten-free meals. Wash utensils thoroughly before each use.
Particular attention to detail:
Clean touch points such as refrigerator door handles with contaminated fingers to prevent the transfer of gluten to surfaces.
Guaranteed purity of oils and products:
Use separate containers for butter, jam and other foods to avoid transferring contaminants to knives and other kitchen tools.
Safe preparation:
Prepare gluten-free meals in separate pots and pans that have been cleaned before use.
Strict cooking rules:
Avoid cooking gluten-free and regular foods in a convection oven at the same time to prevent transfer of particles through the circulating air.
Progressive methods in treatment
Gluten absorption can be prevented by sealing tight junctions with larazotide acetate;
research has begun on TG2 inhibition and modulation of the immune system, as well as blocking HLA-DQ2;
induction of gluten tolerance has been established using Nexvax2, a new peptide epitope immunotherapy based on the principle of desensitization therapy for allergic conditions
Of particular interest is the treatment of refractory celiac disease. According to a retrospective study, budesonide provided clinical remission and recovery in approximately 90% of both types of refractory celiac disease.
In addition to diet modification, a number of ongoing clinical studies have shown promising results in the treatment of celiac disease, but these require further study:
oral gluten-digesting enzyme supplements tested: Latiglutinase (IMGX-003 or ALV-003), AN-PEP (prolyl endopeptidases derived from Aspergillus niger) and STAN1 (microbial enzyme cocktail);
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